EQUINE WOUND MANAGEMENT

29. Ishida Y, Kondo T, Takayasu T, et al: The essential involvement of cross-talk between IFN-gamma and TGF-beta in the

skin wound-healing process. J Immunol 2004;172:1848

30. Howard RD, McIlwraith CW, Trotter GW, et al: Cloning of equine interleukin 1 alpha and equine interleukin 1 beta

and determination of their full-length cDNA sequences. Am J Vet Res 1998;59:704

31. Howard RD, McIlwraith CW, Trotter GW, et al: Cloning of equine interleukin 1 receptor antagonist and determination

of its full-length cDNA sequence. Am J Vet Res 1998;59:712

32. Lin ZQ, Kondo T, Ishida Y, et al: Essential involvement of IL-6 in the skin wound-healing process as evidenced by

delayed wound healing in IL-6–defi cient mice. J Leukoc Biol 2003;73:713

33. Moyer KE, Saggers GC, Allison GM, et al: Effects of interleukin-8 on granulation tissue maturation. J Cell Physiol

2002;193:173

34. Moroguchi A, Ishimura K, Okano K, et al: Interleukin-10 suppresses proliferation and remodeling of extracellular

matrix of cultured human skin fi broblasts. Eur Surg Res 2004;36:39

35. Mori R, Kondo T, Ohshima T, et al: MMP-1 and TIMP-1 mRNA expression were markedly increased with IL-6 and

TNF-alpha treatment and remains unchanged with IL-1beta. Burns 2003;29:527

36. Saika S, Ikeda K, Yamanaka O, et al: Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-

mediated pathogenic tissue response during wound healing. Am J Pathol 2006;168:1848

37. Su X, Deem Morris D, McGraw RA: Cloning and characterization of gene TNF

α encoding equine tumor necrosis factor

alpha. Gene 1991;107:319

38. Igarashi A, Okochi H, Bradham DM, et al: Regulation of connective tissue growth factor gene expression in human

skin fi broblasts and during wound repair. Mol Biol Cell 1993;4:637

39. Grotendorst GR: Connective tissue growth factor: A mediator of TGF-

β action on fi broblasts. Cytokine Growth Factor

Rev 1997;8:171

40. Blom IE, Goldschmeding R, Leask A: Gene regulation of connective tissue growth factor: new targets for antifi brotic

therapy? Matrix Biol 2002;21:473

41. Ollivier FJ, Brooks DE, Schultz GS, et al: Connective tissue growth factor in tear fi lm of the horse: detection, identifi ca-

tion and origin. Graefes, Arch Clin Exp Ophthalmol 2004;242:165

42. Haase I, Evans R, Pofahl R, et al: Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1-

and EGF-dependent signaling pathways. J Cell Sci 2003;116:3227

43. Stewart F, Power CA, Lennard SN, et al: Identifi cation of the horse epidermal growth factor (EGF) coding sequence

and its use in monitoring EGF gene expression in the endometrium of the pregnant mare. J Mol Endocrinol
1994;12:341

44. Li Y, Fan J, Chen M, et al: Transforming growth factor-alpha: a major human serum factor that promotes human kera-

tinocyte migration. J Invest Dermatol 2006;126:2096

45. Ono M, Okamuro K, Nakayama Y, et al: Induction of human microvascular endothelial tubular morphogenesis

by human keratinocytes: Involvement of transforming growth factor-alpha. Biochem Biophys Res Commun
1992;189:601

46. Sorensen OE, Cowland JB, Theilgaard-Monch K, et al: Wound healing and expression of antimicrobial peptides/poly-

peptides in human keratinocytes, a consequence of common growth factors. J Immunol 2003;170:5583

47. Abraham JA, Klagsbrun M: Modulation of wound repair by members of the fi broblast growth factor family. In RAF

Clark ed. The molecular and cellular biology of wound repair (2nd edition). New York: Plenum Press, 1996, p. 195

48. Kuwabara K, Ogawa S, Matsumoto M, et al: Hypoxia-mediated induction of acidic/basic fi broblast growth factor and

platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl
Acad Sci USA 1995;92:4606

49. Welter H, Bollwein H, Einspanier R: Direct submission to GenBank (AJ319906) for Equus caballus FGF-2, 2002
50. Taylor WR, Alexander RW: Autocrine control of wound repair by insulin-like growth factor 1 in cultured endothelial

cells. Am J Physiol 1993;265:C801

51. Ando H, Jensen PJ: EGF and IGF-1 enhance keratinocyte migration. J Invest Dermatol 1993;100:633
52. Dunaiski V, Belford DA: Contribution of circulating IGF-I to wound repair in GH-treated rats. Growth Horm IGF Res

2002;12:381

53. Ghahary A, Shen Q, Shen YJ, et al: Induction of transforming growth factor beta 1 by insulin-like growth factor-1 in

dermal fi broblasts. J Cell Physiol 1998;174:301

54. Otte K, Rozell B, Gessbo A, et al: Cloning and sequencing of an equine insulin-like growth factor I cDNA and its

expression in fetal and adult tissues. Gen Comp Endocrinol 1996;102:11

55. Beer HD, Gassmann MG, Munz B, et al: Expression and function of keratinocyte growth factor and activin in skin

morphogenesis and cutaneous wound repair. J Investig Dermatol Symp Proc 2000;5:34

56. Werner S: Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev

1998;9:153

57. Robson MC, Phillips TJ, Falanga V, et al: Randomized trial of topically applied repifermin (recombinant human kera-

tinocyte growth factor-2) to accelerate wound healing in venous ulcers. Wound Repair Regen 2001;9:347