Biotechnology in Oral Care
Martyna Adamska Mateusz
Kręcisz
Biotechnology in Oral Care
Martyna Adamska Mateusz
Kręcisz
A few words about
Introduction
Etiology and pathogenesis of oral
problems
The periodontal diseases
Current routes to control and prevent
dental plaque formation
Dental caries and periodontal diseases
Affect many people in various age
Poor hygene of oral cavity is the the
cause
Dental plaque - the interplay
between plaque bacteria and the
host tissues
Periodontal diseases
Meticulous of gingival flora to anaerobic
bacteria
Numbers of bacteria are the risk factor
P. gingivalis, B. forsythus, and T. denticola
– chronic periodontitis
A. actinomycetemcomitans – rapidly
periodontitis
Individual host risk factors
Prevention and control
Meticulous oral hygiene and the
mechanical removal of dental plaque
from all tooth surfaces
Fluoride
Antimicrobial agents
Enzyme systems
Fluoride
Only one clincally accepted anticaries
agent for routine use
Maintain of low concentration of fluoride
in plaque
Fluoride water (0.1 – 1 ppm)
Fluoride toothpaste (1000 – 1500 ppm)
used twice a day
Small devices placed on tooth releasing
fluoride
Antimicrobial agents
Few antimicrobial agents have been
successfully formulated into commercial
products
Among these are three mouth rinses
chlorhexidine (CHX)
Cetylpyridinium chloride (CPC)
Essential oils
Two toothpastes containing triclosan
With coopolymer
Zinc nitrate
Enzymes
Minor role in treatment of oral
diseases
Current enzyme products have not
been proven to prevent or reduce
dental plaque formation
Effects of poor hygiene of mouth
Enzyme Systems
• Glucan,
• Fructan hydrolase,
• Dextranase,
• Mutanase,
• Lactoperoxidase,
• Krill enzymes.
Vaccines and Other Immunogenic Routes to Reduce
Bacterial
Infections and Prevent Oral Disease
• Anti caries vaccine
• Controversial !!
• Costs,
• Antigen 1/11
• clone the genes encoding selective
antibodies
• monoclonal antibody to P. gingivalis
Replacement Therapy and the Use of
Pro- and Prebiotics
• This strain of S.
mutans has been
successfully implanted
in rodents and
resulted in reduced
levels of caries.
• bacteriocin-like sub-
stances
• to prevent oral
malodor
Antimicrobial Peptides
• Natural
antimicrobial
peptides,known as
defensins.
Phage-Encoded Enzymes and
Proteins
• The concept of
cloning genes
• Producing
therapeutic or
pharmacological
DZIĘKUJEMY ZA UWAGĘ ;)
