Epidemiology and 

Prevention of Viral 

Hepatitis A to E:

Hepatitis D (Delta) Virus

Division of Viral Hepatitis

HBsAg

RNA

 

antigen

Hepatitis D (Delta) Virus

Low

HDV Prevalence

High

Intermedi
ate

Very Low

No 
Data

Taiwan

Pacific Islands

Geographic Distribution of HDV 

Infection

•

Coinfection with HBV

–

severe acute disease

–

low risk of chronic infection

•

Superinfection on top of chronic 

HBV

–

usually develop chronic HDV infection

–

high risk of severe chronic liver disease

 

Hepatitis D -  Clinical Features

HBV – HDV 

Coinfection

Typical Serological 

Course

Time after Exposure

Anti-HBs

Symptoms

ALT Elevated

Total anti-HDV

IgM anti-HDV

HDV  RNA

HBsAg

T

it

e

r

HBV – HDV Super-infection

Typical Serological Course

Jaundice

Symptom

s

ALT

Total anti-HDV

IgM anti-HDV

HDV RNA

HBsAg

T

it

e

r

Time after Exposure

•

Percutanous 

exposures



injecting drug use

•

Permucosal 
exposures



sex contact

 

Hepatitis D Virus

Modes of Transmission

•

HBV-HDV Coinfection

–

Pre or postexposure prophylaxis to 

prevent HBV infection (HBIG and/or 

Hepatitis B vaccine)

•

HBV-HDV Superinfection

–

Education to reduce risk behaviors 
among persons with chronic HBV 
infection

 

Hepatitis D - Prevention